The National Tuberculosis Institute (NTI), Bangalore has validated Hinduja Hospital’s study that confirms drugs resistance to all the known TB drugs (first and second line) in eight patients whose samples were re-tested.
On 6 January 2012, Hinduja Hospital had announced that they had detected 12 totally drug resistant (TDR) TB cases, a terminology that was not accepted by the World Health Organization (WHO). Drugs resistance is developed because of mismanagement of multi-drug resistant tuberculosis (MDR-TB). They had published the study in the scientific publication Clinical Infectious Diseases on 21 December 2011.
However, after the Central Tuberculosis Division (CTD), with their team of experts including NTI, arrived in Mumbai to take stock of the situation, they said that the patients suffered from XXDR-TB, which in medical literature is extremely drug-resistant tuberculosis. Of the 12 cases, eight samples were then sent for re-testing to NTI.
“Of the eight samples sent, two patients died early this year (2012). The other six patients live in Mumbai, one of who is a 15-year-old. Five of these patients are undergoing treatment with the Revised National Tuberculosis Control Programme (RNTCP) for extensively drugs resistant (XDR) TB, while one is being treated at the Hinduja Hospital,” said Dr. Minni Khetarpal, city TB officer, Brihanmumbai Municipal Corporation.
“The NTI has confirmed the Hinduja report. We will place this report on record before the Directly Observed Treatment Shortcourse (DOTS) committee and figure out the future line of treatment that could be offered to these patients now,” said Dr P.Y. Gaikwad, state TB officer.
However, Dr Gaikwad added that two of these patients are sensitive to one second-line drug. “All the other patients are doing well. It shows that immunity of the host (patient) also matters, not just the drug sensitivity to the bacteria. Many of these patients are working for a living,” said Dr Gaikwad.
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