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Available at http://jvi.asm.org/content/early/2013/05/08/JVI.01244–13.long
Excerpt. During the summer of 2012, in Jeddah, Saudi Arabia a hitherto unknown coronavirus was isolated from the sputum of a patient with acute pneumonia and renal failure. The isolate was provisionally called human coronavirus EMC. Shortly thereafter, September 2012, the same type of virus, named human coronavirus England 1, was recovered from a patient with severe respiratory illness, who had been transferred from the Gulf region of the Middle East to London, United Kingdom. The onset of the new disease was traced back to an even earlier time point. Already in April 2012, a cluster of pneumonia cases in health care workers occurred in an intensive care unit of a hospital in Zarqa, Jordan. Two persons died, both of which were confirmed to have been infected with the novel coronavirus through retrospective analysis of stored samples. These findings met with considerable concern. Although the number of cases documented is limited (thirty as of 6 May 2013), the morbidity and mortality of the infection is alarming, as is its uncanny resemblance –at least in its clinical features– to SARS. While a small minority of the known cases developed mild disease, most patients presented with a severe acute respiratory condition requiring hospitalization; the mortality rate is approximately 60%.