In a major cause for concern, a new strain of cholera bacteria resistant to third generation antibiotics has been found to be circulating in India. This cholera bacterial strain contains two super bug genes including the notorious New Delhi Metallo beta-lactamase-1 (blaNDM-1). The other super bug gene is plasmid-mediated beta-lactamase-1 (blaDHA-1). Thanks to these two super bug genes, the new cholera bacterial strain (O1 El Tor Ogawa) has developed resistance to a majority of known antibiotics.
The blaNDM-1, discovered a couple of years ago from hospitals in New Delhi, created ripples in the health sector worldwide. The gene was then found in Escherichia coli strains. This is the first time that doctors have found the super bug gene blaNDM-1 in the cholera bacteria Vibrio cholerae.
A team of doctors led by Dr. Jharna Mandal from Jawaharlal Institute of Post-graduate Medical Education and Research (Jipmer), Puducherry, isolated the cholera germ strain from the stool of a two-year-old patient. It reported the findings in the journal of the Centres for Disease Control and Prevention (CDC), USA.
“Vibrio cholerae have developed enormous capabilities to combat antimicrobial drug effects. It possesses efflux pumps that act on multiple classes of antimicrobial drugs and elaborates enzymes that can nullify the impact of complex antimicrobial drugs,” the team said.
The full article may be accessed at http://www.promedmail.org/direct.php?id=20120801.1224333
(ProMED 8/1/2012)