India: H5N1 avian influenza strikes poultry farm

Highly path­o­genic H5N1 avian flu has struck a poul­try farm in Bihar state, India, killing 338 birds, accord­ing to the World Orga­ni­za­tion for Ani­mal Health (OIE). The report says 4,000 birds are sus­cep­ti­ble but does not say whether culling of the remain­ing birds is planned to stop dis­ease spread. Offi­cials are inves­ti­gat­ing the source of the virus, adding, “An inten­sive sur­veil­lance cam­paign has been launched in a 10 km radius zone.” The premises will be dis­in­fected. Bihar state is near India’s bor­ders with Nepal and Bangladesh. The country’s last H5N1 out­break was in Octo­ber 2012.

(CIDRAP 3/9/2013)

Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes — Bangladesh, China, and India, 2006–2008

United States Cen­ters for Dis­ease Con­trol and Pre­ven­tion (US CDC). MMWR. 14 Decem­ber 2012. 61(49):1008–11.
Avail­able at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6149a3.htm

Excerpt. Qual­ity sur­veil­lance is crit­i­cal to the con­trol and elim­i­na­tion of vaccine-preventable dis­eases (VPDs). A key strat­egy for enhanc­ing VPD sur­veil­lance, out­lined in the World Health Orga­ni­za­tion (WHO) Global Frame­work for Immu­niza­tion Mon­i­tor­ing and Sur­veil­lance (GFIMS), is to expand and link exist­ing VPD sur­veil­lance sys­tems (par­tic­u­larly those devel­oped for polio erad­i­ca­tion and measles elim­i­na­tion) to include other pri­or­ity VPDs. Since the launch of the Global Polio Erad­i­ca­tion Ini­tia­tive in 1988, the inci­dence of polio has decrease by 99% world­wide. A cor­ner­stone of this suc­cess is a sen­si­tive sur­veil­lance sys­tem based on the rapid and timely report­ing of all acute flac­cid paral­y­sis (AFP) cases in chil­dren aged <15 years, with con­fir­ma­tory diag­nos­tic test­ing per­formed by lab­o­ra­to­ries that are part of a global net­work. As coun­tries achieve polio-free sta­tus, many have expanded syn­dromic sur­veil­lance to include per­sons with rash and fever, and have built measles diag­nos­tic capac­ity in exist­ing polio ref­er­ence lab­o­ra­to­ries. Acute meningitis/encephalitis syn­drome (AMES) and acute encephali­tis syn­drome (AES) are can­di­dates for expanded sur­veil­lance because they are most often caused by VPDs of pub­lic health impor­tance for which con­fir­ma­tory lab­o­ra­tory tests exist. Vaccine-preventable cases of encephali­tis include approx­i­mately 68,000 Japan­ese encephali­tis (JE) cases, result­ing in 13,000–20,000 deaths each year in Asia. More­over, although bac­te­r­ial menin­gi­tis inci­dence in Asia is not as well-documented, pneu­mo­coc­cal and meningo­coc­cal menin­gi­tis out­breaks have been reported in Bangladesh and China, and the inci­dence of Haemophilus influen­zae type b (Hib) menin­gi­tis in chil­dren aged <5 years in India has been esti­mated to be 7.1 per 100,000 pop­u­la­tion, sim­i­lar to that in Euro­pean coun­tries before the intro­duc­tion of vac­cine. This report describes a pro­to­type for expand­ing exist­ing polio and measles sur­veil­lance net­works in Bangladesh, China, and India to include sur­veil­lance for viral and bac­te­r­ial vaccine-preventable causes of AMES and AES and presents data from 2006–2008.

India: NDM-1 carrying Vibrio cholerae, cholera superbug found

In a major cause for con­cern, a new strain of cholera bac­te­ria resis­tant to third gen­er­a­tion antibi­otics has been found to be cir­cu­lat­ing in India. This cholera bac­te­r­ial strain con­tains two super bug genes includ­ing the noto­ri­ous New Delhi Met­allo beta-lactamase-1 (blaNDM-1). The other super bug gene is plasmid-mediated beta-lactamase-1 (blaDHA-1). Thanks to these two super bug genes, the new cholera bac­te­r­ial strain (O1 El Tor Ogawa) has devel­oped resis­tance to a major­ity of known antibiotics.

The blaNDM-1, dis­cov­ered a cou­ple of years ago from hos­pi­tals in New Delhi, cre­ated rip­ples in the health sec­tor world­wide. The gene was then found in Escherichia coli strains. This is the first time that doc­tors have found the super bug gene blaNDM-1 in the cholera bac­te­ria Vib­rio cholerae.

A team of doc­tors led by Dr. Jharna Man­dal from Jawa­har­lal Insti­tute of Post-graduate Med­ical Edu­ca­tion and Research (Jip­mer), Puducherry, iso­lated the cholera germ strain from the stool of a two-year-old patient. It reported the find­ings in the jour­nal of the Cen­tres for Dis­ease Con­trol and Pre­ven­tion (CDC), USA.

Vib­rio cholerae have devel­oped enor­mous capa­bil­i­ties to com­bat antimi­cro­bial drug effects. It pos­sesses efflux pumps that act on mul­ti­ple classes of antimi­cro­bial drugs and elab­o­rates enzymes that can nul­lify the impact of com­plex antimi­cro­bial drugs,” the team said.

The full arti­cle may be accessed at http://www.promedmail.org/direct.php?id=20120801.1224333
(ProMED 8/1/2012)