Improving skeletal muscle function with age would have a significant impact on quality of life in the elderly. Sarcopenia is the age-related loss of muscle contractility as well as muscle atrophy. This loss of both quality and quantity of muscle is an important public health concern due to its role in increased morbidity and nursing home placement. Poor muscle function is associated with exercise intolerance and fatigue, which lead to poor quality of life, loss of independence, and age-related diseases. This loss of independence is due to an inability to perform activities of daily living that require sustained muscle power, such as walking, dressing, and showering as well as increased risk of falling. The resulting increased rates of nursing home placement and hospitalization make the loss of skeletal muscle function with age a growing public health crisis in terms of both quality of life and economic costs to society. Janssen et al.estimated these costs at $18 billion dollars in 2001 and predicted that a 10% reduction in sarcopenia prevalence would lead to a savings of $1.4 billion in healthcare costs (adjusted to 2010 dollars). Despite this, there are few treatment options to reverse muscle degeneration in the elderly due in large part to the poor understanding of the mechanisms that underlie this dysfunction. A major interest in our lab is identifying new interventions that have the potential to translate into elderly patients to improve muscle function and quality of life.