New Therapies

Bringing New Therapies to the Bedside

​All new therapies, biomarkers or other medical discoveries must be tested in patients through clinical trials. This complex and demanding process requires a high degree of compassion and medical expertise, as well as communication and organizational skills. Thus many specialized experts working closely as a team.

The IPCR has two integrated clinical trials teams: one focused on developing and testing therapies for advanced disease; and the other developing and testing therapies designed to be used with surgery and radiotherapy for treating localized prostate cancers (those in which tumors are only in the prostate and have not spread to other organs in the body).

Many of the clinical trials are unique to Seattle. Several new research studies, called novel studies, involve the first evaluation of new therapeutic treatments in people. Other trials involve more than one research institution and originate through cooperation with leading national clinical trials groups involving the major cancer centers in the United States and abroad.

IPCR clinical trials include some of the most innovative therapies currently being evaluated nationally. The institute includes one of 10 National Cancer Institute-funded prostate cancer Specialized Programs of Research Excell​ence (SPORE). As a result, IPCR physicians participate in new therapy trials often available only to that group, allowing UW Medicine patients to receive new, better treatments as quickly as possible.

IPCR clinical trials researchers are also members of the Department of Defense Prostate Cancer Clinical Trials Consortium and have access to many trials conducted by this special group of 12 leading prostate cancer centers in the United States.

Our clinical trial accomplishments

Molecular Studies in localized disease:

  • Neoadjuvant therapy, giving other treatments before the traditional primary treatment for a localized disease, has improved the outcomes of many cancer patients. In the past, these therapies have been slow to reach many cancer patients because their success could be judged only after many years of follow-up and study.

    IPCR researchers have helped pioneer a new, quicker approach for evaluating neoadjuvant therapies. At the time of the primary surgery or just before radiation therapy, physicians take a cancer specimen for molecular analysis. In this way, scientists are able to tell more quickly whether a new therapy is effective by looking at the way molecules in the cancer specimen react to the therapy.

  • So far, the IPCR team has conducted large neoadjuvant molecular studies of chemotherapy drugs and, more recently, of newer hormone therapies. Many more molecular neoadjuvant studies are in the planning stages.
  • Every tumor (and patient) has unique characteristics, dictated by gene variations. The molecular analyses of cancers provide an opportunity for researchers to develop a personalized approach to treating and following a patient’s particular cancer.

Innovative treatments for advanced disease:

  • Although suppressing testosterone and administering chemotherapy prolong survival for men with advanced prostate cancer, most cancers eventually develop resistance to these interventions. IPCR investigators have conducted Phase I, first-in-human, trials designed to block tumors’ resistance mechanisms, allowing patients in the Northwest to be the first recipients of treatments resulting from these promising laboratory findings.
  • Encouraging results from novel studies involving antibodies targeting the Insulin-like Growth Factor-1 Receptor (IGF-1R) and small molecules targeting the stress response protein clusterin, have led to clinical trials designed to substantially improve the longevity of men with advanced prostate cancer.
  • IPCR investigators are also key participants in trials involving new effective therapies developed elsewhere, such as Provenge, abiraterone, and MDV-3100.

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    Harley Quinn was last seen in Birds of Prey with her apprentice Cassandra Cain. But, come The Suicide Squad, she’s back in prison.

    Viewers who haven’t seen 2016’s Suicide Squad may still go to James Gunn’s The Suicide Squad cold. It is, however, still in continuity to its predecessor and subsequent DC Extended Universe films. So it doesn’t mean much for most characters of Task Force X. They are either new characters to DC’s loose cinematic universe or no appearance since Suicide Squad.

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    Although Harley was a good friend to the Birds, Harley Quinn wasn’t interested in joining the group. Canary, Huntress, and Montoya formed a bond over tacos, and Harley and Cassandra ran away with the MacGuffin, the diamond in the film. To make Canary’s escape even more complicated, Harley took Canary’s car. Harley considers the Birds “dorky little good-willers” even though she could work well with them. Harley did throw the Birds a bone by allowing Huntress to access her family fortune through bank codes encoded on the diamond. Harley took the diamond and made money with Cassandra, her “apprentice”.

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    But in fact, this rough plan can not earn large profit and get a long-term development.

    You also need to know some skills to start your second hand clothing business.

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    Make clear purchase plans before starting buy used clothing.

    Clearly know the location of used clothes supplier and choose the appropriate distance.

    More and more, have a specific plan to save time when you go to the used clothes market.

    2: How Many Goods Should You Take?
    Generally speaking, choose the reliable supplier in second hand clothing business line.

    Go to the factory to test the quality of used clothing and check the supplier chain.

    Prepare two funds, one is the clothing purchasing funds, the other is replenishment funds of other trivial things, taking a little balance between them.

    3: Choose Various Styles Of Goods:
    Do not choose few styles to start your used clothes business.

    In order to satisfy various need of customers, you should choose various styles of second hand kid clothing,used man clothes or used woman clothes.

    4: Pay Attention To The Sizes:
    Pay attention to size when purchases used clothing.

    Trying several kinds of size: normal size of clothing, plus size second hand women/man clothing and extra small size second-hand clothes.

    When you ask workers to pack, be careful to see if there is any wrong packing way.

    5: Seize The Discount Opportunity:
    Seize the opportunity of the discount. Focus on the weekends, holidays and other promotion time.

    If there is a promotion, you should purchased used clothing in bale immediately to save your money.

    6: Know More Specific Information:
    Contact with the supplier to learn more about regional consumption information, you can know the popular styles of second hand clothing.

    Finally, analyzing the climate, consumers’ economic ability and aesthetic views of second hand clothing and so on.

    Then flexible use these useful information to buy bulk second hand clothes .

    7: Know More Knowledge Of Used Clothing:
    Be sure to know knowledge of used clothes:No pilling, No stains, No broken, No dirty, No slack.

    Choose the high quality second hand clothing to earn more money.

    8: Choose The Reliable Supplier:
    Reliable supplier would provide you high quality second hand clothing&bags&shoes.

    And they can provide you reliable logistics transportation team to ship products smoothly and timely.

    As well as the supplier chain, do not find small factory to be your supplier, they will out of stock anytime.

    9: Warehouse Storage:
    Storage is also a very important factor.

    As we all know, no matter how good your second hand products are, if they are affected by damp and moldy weather,then your goods will be affected seriously.

    Your goods should be carefully protected from moisture and fire away.

    By laying a few thick layers of moisture-proof plastic bags to protect products.

    Selecting Used Clothes

    Used Clothing Wholesale

    Hot Selling Market In Africa
    When a big bag second hand clothes were opened, the crowd gathered together.

    While the clothes like used dresses, which can sell for $7 or $8.

    As the selection of used items dwindled, retailers began offering discounts to solve the left stock.

    Second Hand Clothes Online

    In the pictures, it show many countries choose china supplier as their second hand clothing business partner.

    At the same time, used clothes ,women dresses, shoes, plus size women’s clothing and handbags are the most popular products.

    The used clothes accounts for the largest proportion, it well received by Africa and other countries.

    For economic reasons and corona virus disease, there are many businessman selling second-hand clothes, used shoes and used bags in many countries in Africa, Asia and Southeast Asia increasingly.

    2021 GDP In The World

    2021 GDP In Africa

    Influenced by the COVID, the export industry of second-hand clothes in countries such as Japan, South Korea, Europe and the United States suffered severe setbacks or even stagnated.

    Many overseas customers chose China supplier as their first choice, which was relatively less affected by the COVID.

    They got a lot of profit from the business of second hand clothes store with China supplier.

    Taking care of their life and living a better life by doing the second hand products business.

    Popular Second Hand Used Clothes
    The Countries Sell Second Hand Clothes

    In addition, picture shows that the United States, Philippines, India, Cambodia and South Africa prefer the used women clothing ,men’ clothing, sportswear and used children clothing.

    Used clothes become the most popular products among the second hand clothing business trade.

    If you want to find the reliable supplier, contacting us to make a deal.
    https://hissenglobal.com/

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