IPCR research related to prostate cancer targets the goals of developing better approaches for preventing, detecting and curing prostate cancer. Categorizing these efforts can be complex. We have divided them into five areas: understanding risk factors, improving screening and diagnosis, enhancing quality of life, understanding prostate cancer progression and bringing new treatments to the bedside.
Understanding prostate cancer risk factors
Lifestyle — diet, alcohol consumption and smoking
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- IPCR studies have shown that four or more, four-ounce glasses of red wine per week yield about a 60 percent lower incidence of the more aggressive types of prostate cancer.
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- IPCR is conducting a nationwide research project called the Prostate Cancer Genetic Research Study (PROGRESS) to understand why some families have several members with prostate cancer. Finding the hereditary genes of prostate cancer is now an international effort in which the IPCR team is a major player.Another effort is to find out and understand why African-American men have a 60 percent higher incidence of prostate cancer than Caucasian-Americans. Indeed IPCR has documented that the frequency of prostate-cancer testing is associated with a patient’s race. Researchers found that African-American men with prostate cancer are half as likely as Caucasian-American men to receive annual PSA tests.
Decoding prostate cancer’s biology for prevention
- IPCR leads an international research team that studies approaches to prostate-cancer prevention by analyzing blood, DNA, prostate biopsy tissue and surgery tissue taken from almost 19,000 study participants.
- IPCR researchers played a major role in The Prostate Cancer Prevention Trial. This large national trial tested whether the drug Finasteride would reduce the prevalence of prostate cancer. The study found that the drug cut the chance of developing prostate cancer by almost 25 percent. This drug and others like it can now be used in some men to reduce their chances of getting prostate cancer.
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