We collaborate with several groups in the area of vitamin A and retinoic acid homeostasis. In the area of importance of retinoic acid in male reproduction our collaborators include John Amory at the UW and Dr’s Michael Griswold and Cathryn Hogart at WSU. We have an active collaboration with Dr Philippe Diaz at University of Montana and with DermaXon to develop specific inhibitors of the CYP26 enzymes to decrease the in vivo clearance of retinoic acid.
In the area of drug-drug interactions and drug-disease interactions we are working closely with the UW Drug Interaction Database to improve the methods of using publicly available data including scientific papers and new drug applications to characterize and better predict in vivo drug-drug and rug-disease interactions.
We have an active collaboration with Dr Wes Van Voorhis at the UW in the area of developing novel therapies for the protozoan pathogens that cause Chagas’ disease (Trypanosoma cruzi), African sleeping sickness (Trypanosoma brucei), leishmaniasis, cryptosporidiosis, toxoplasmosis, and malaria.