This article goes straight to the heart of the challenge of tailoring care to each individual patient. Such a tailoring challenge bumps up against algorithmic appropriateness analyses, particularly those which are computerized for decision support. Generalized appropriateness may not ideally apply to individual patients and their unique situations.

How we balance these challenges is to be worked out – to fail at this challenge would be to compromise care, both overall and individually. The coming 5 years will be very interesting for this balance.