We have a developed a predictive environment and gene regulatory influence network (EGRIN) for S. Cerevisiae. This network uses publicly available and in-house gene expression data from microarrays to predict genetic regulation and cellular responses. We intend to expand it to a stochastically robust EGRIN 2.0 that we will use to engineer yeast to produce economically relevant compounds in peroxisomes.
10-week Project #1: Write a framework for generating multiple EGRINs so that the EGRIN 2.0 can be generated with additional processor time. This project would involving using the gene biclustering program cMonkey in [R] or python and interacting with a Sun Grid Engine cluster. There would be plenty of opportunity to improve the cMonkey algorithm.
Familiarity with the [R] statistical programming language or Python.
Familiarity with Unix shell scripting and cluster computing using the Sun Grid Engine (SGE) or similar system.
The Washington Nanofabrication Facility (WNF) is the premier cleanroom for conducting research and development in nanofabrication and sensor domains (MEMS, biosensors, electronic/photonic devices) in the Pacific Northwest. Over 40 companies conduct R&D activities in the WNF along with over 80 principle investigators from UW and other research institutions. Currently, the WNF is offering Internal Research and Development (IR&D) projects for defining new processes and assisting in the fabrication of leading-edge devices as part of the foundry model.
Students can leverage this experience to gain access to direct hiring by WNF client companies or establish a critical skill set to get a competitive advantage for graduate school applications. Project complexity and depth will vary depending on student availability and can range from refining a single process, exploring new materials properties, aiding staff in fabricating a device, to establishing completely new manufacturing/processing technologies and fabrication flows.
Given the in-depth training and time needed to become proficient in fabrication technology, preference will be given to students willing to make extended commitments (> 6 months) and with a minimum of 5-10 hours/week of regular availability.
All requisite training will be provided. Candidates should demonstrate proficiency in critical thinking, consistency in establishing/following protocols/procedures, detailed technical documentation and reporting. WNF users and applications span all domains of engineering as well as physical and life sciences.
Are you a undergraduate science student at the UW – physical sciences, biological sciences, ChemE or BioE? Then don’t miss the first-ever Science Job & Internship Fair!
Science Job & Internship Fair January 30, 20142:00-5:00pm, MGH Commons
This unique mini-career fair will give you the opportunity to connect directly with recruiters from local and/or national companies who are looking to hire UW science students for job or internship opportunities.
We develop advanced structures and sensing systems for aerospace, mechanical, and biomedical applications. These novel material systems include composite materials, phononic crystals, and metamaterials. They are more responsive, safer, and better performing with a range of applications in aerospace, civil and mechanical structures. We are also working on sensing devices that evaluate systems with more accuracy and control.
We are looking for students to work with mouse models of altered mitochondrial function and/or cell metabolism to investigate disease mechanisms. The student will be involved in treatment of mouse models, monitoring physiological function of multiple organ systems, and biochemical analysis of tissue samples. Molecular and genetics analysis will be included in the later stage of the project.
Comfortable to work with animals.
General knowledge of biology, biochemistry and physiology.
A minimum of 10 hours per week needed.